diff --git a/Doc/library/ctypes.rst b/Doc/library/ctypes.rst
index 6f3524e0253bca..9ce441b09039c3 100644
--- a/Doc/library/ctypes.rst
+++ b/Doc/library/ctypes.rst
@@ -1584,6 +1584,14 @@ way is to instantiate :py:class:`CDLL` or one of its subclasses:
    they are not added automatically.
    See :ref:`ctypes-finding-shared-libraries` for more information.
 
+   On macOS, a *name* that is not an absolute path may only be searched
+   for in system locations such as :file:`/usr/lib`. Libraries and
+   frameworks in folders like :file:`/usr/local/lib`, :file:`~/lib` or
+   :file:`~/Library/Frameworks` are then not found, so pass the full path.
+   Setting :envvar:`!DYLD_LIBRARY_PATH` or :envvar:`!DYLD_FRAMEWORK_PATH`
+   before starting Python adds search locations, but macOS ignores these
+   variables for some executables.
+
    On non-Windows systems, *name* can  be ``None``. In this case,
    :c:func:`!dlopen` is called with ``NULL``, which opens the main program
    as a "library".
diff --git a/Misc/NEWS.d/next/Documentation/2026-11-08-16-26-47.gh-issue-88130.JVOGb1.rst b/Misc/NEWS.d/next/Documentation/2026-11-08-16-26-47.gh-issue-88130.JVOGb1.rst
new file mode 100644
index 00000000000000..f5b923d05a73d6
--- /dev/null
+++ b/Misc/NEWS.d/next/Documentation/2026-11-08-16-26-47.gh-issue-88130.JVOGb1.rst
@@ -0,0 +1,2 @@
+Document that :class:`ctypes.CDLL` on macOS may not find libraries in
+:file:`/usr/local/lib` or user folders unless given a full path.